{"id":5961,"date":"2018-02-20T16:11:51","date_gmt":"2018-02-20T16:11:51","guid":{"rendered":"https:\/\/www.fundacioolgatorres.org\/2022\/03\/15\/important-scientific-discovery-with-funding-from-the-fot\/"},"modified":"2023-07-26T15:51:23","modified_gmt":"2023-07-26T15:51:23","slug":"important-scientific-discovery-with-funding-from-the-fot","status":"publish","type":"post","link":"https:\/\/www.fundacioolgatorres.org\/en\/2018\/02\/20\/important-scientific-discovery-with-funding-from-the-fot\/","title":{"rendered":"Important scientific discovery with funding from the FOT"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5961\" class=\"elementor elementor-5961 elementor-2947\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-01cc075 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"01cc075\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e6c3ac1\" data-id=\"e6c3ac1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-72fe8ea elementor-widget elementor-widget-heading\" data-id=\"72fe8ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Important scientific discovery with funding from the FOT<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fe8a440 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fe8a440\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fd6b9f9\" data-id=\"fd6b9f9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bdef1f3 elementor-widget elementor-widget-image\" data-id=\"bdef1f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"512\" src=\"https:\/\/www.fundacioolgatorres.org\/wp-content\/uploads\/2021\/12\/radioterapia-768x512.jpg\" class=\"attachment-medium_large size-medium_large wp-image-4152\" alt=\"\" srcset=\"https:\/\/www.fundacioolgatorres.org\/wp-content\/uploads\/2021\/12\/radioterapia-768x512.jpg 768w, https:\/\/www.fundacioolgatorres.org\/wp-content\/uploads\/2021\/12\/radioterapia-300x200.jpg 300w, https:\/\/www.fundacioolgatorres.org\/wp-content\/uploads\/2021\/12\/radioterapia-1024x682.jpg 1024w, https:\/\/www.fundacioolgatorres.org\/wp-content\/uploads\/2021\/12\/radioterapia-1536x1024.jpg 1536w, https:\/\/www.fundacioolgatorres.org\/wp-content\/uploads\/2021\/12\/radioterapia.jpg 2000w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b0ae66d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b0ae66d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48fb7fe\" data-id=\"48fb7fe\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-05f83e8 elementor-widget elementor-widget-text-editor\" data-id=\"05f83e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div><ul><li>A team headed by ICREA researcher <strong>Eduard Batlle <\/strong>discovers that immune system-stimulating treatments combined with a TGF-beta inhibitor are effective against colon cancer.<br><br><\/li><li>The researchers developed a mouse model that mimics advanced human colon cancer. This model has allowed them to study the immune system response for the first time.<br><br><\/li><\/ul><i>Barcelona, Wed. 14 February 2018.-<\/i> In a short space of time, immunotherapy, that is to say therapies based on stimulating the immune system against cancer cells, has become a powerful approach to treat cancers such as melanoma and lung cancer. However, to date, most colon tumours appeared to be unresponsive to this kind of therapy. Given this observation, it was hypothesized that this kind of tumour was simply invisible to the immune system. In a study published today in the journal Nature, a team headed by ICREA researcher, <a href=\"https:\/\/www.irbbarcelona.org\/ca\/research\/colorectal-cancer-laboratory\" target=\"_BLANK\">Eduard Batlle<\/a>, at the Institute for Research in Biomedicine (IRB Barcelona), <strong>explains that the hormone <i>TGF-beta<\/i>is responsible for the \u201cblindness\u201d of the immune system to colon cancer cells<\/strong><br><br><strong>&#8220;The few clinical immunotherapy trials done in patients with the most common subtype of colon cancer were not giving good results and we didn\u2019t understand why this was happening,&#8221;<\/strong> explains <strong>Eduard Batlle.<\/strong><br><br><strong>By inhibiting the activity of TGF-beta, the cells of the immune system infiltrate and recognise the tumour, <\/strong>fight the cancer, and even stop colon tumours from metastasizing to the liver and lung in a preclinical mouse model that mimics the human disease <strong>In addition, and more importantly, the researchers have demonstrated that the combination of a TGF-beta inhibitor with available immunotherapies boost the anti-tumour effect<\/strong> allowing the immune system to efficiently eliminate already established metastases, which would otherwise kill the individual in a question of weeks.<br><br><h3>Model that mimics aggressive human colon cancer<\/h3><br>The scientist<strong>Daniele Tauriello<\/strong>, postdoctoral fellow and first author of the article, induced four of the most common mutations present in advanced human colon tumours in mice. <strong>&#8220;The development of the animal model took us four years but we hit the nail on the head,\u201d<\/strong>, he says.<br><br>After confirming the similarity of the mouse tumours with those in humans, they built a biobank of tumour organoids\u20143D mini-tumours\u2014 to then graft them in a controlled manner in immunocompetent mice. <strong>&#8220;For studies of the immune system, the tumour has to be of mouse origin otherwise the animal would reject it,\u201d<\/strong>he explains This animal model, which mimics the main features of metastatic colon cancer in patients, allowed the researchers to examine how cancer cells evade the immune system.<br><br><h3>Beyond colon cancer<\/h3><br>Around 40 to 50% of colon cancer patients relapse in the form of metastasis, with the tumours reproducing mainly in the liver and lung. <strong>&#8220;Once a diagnosis of advanced stage colon cancer is given, oncologists do not have access to efficient treatments to cure the patient,\u201d<\/strong>, explains <strong>Eduard Batlle<\/strong>.<br><br>This study paves the way for the development of the first treatment based on immunotherapy for patients with metastatic colon cancer and for those patients with poor prognosis but who have not yet developed metastasis.<br><br><strong>&#8220;Oncologists and pharmaceutical companies will soon start clinical assays that combine TGF-beta inhibitors, which are already in clinical use, with immunotherapies. We are convinced that many colon cancer patients will benefit from this therapeutic strategy,\u201d<\/strong>, they say.<br><br><i>In the same issue of Nature there is another study that addresses the lack of response of bladder cancer patients to immunotherapy. Conducted by the North American pharmaceutical company Genentech, this study draws the same conclusions as Batlle\u2019s team<\/i> <strong>&#8220;This second study demonstrates that the discovery goes beyond colon cancer. It appears that many types of tumour use the same strategy\u2014increasing the expression of TGF-beta in the environment\u2014to evade the immune system. Patients with these tumours may also benefit from immunotherapies based on the inhibition of this hormone,\u201d<\/strong>say the scientists at IRB Barcelona.<br><br>The study has involved collaboration with the chemistry lab headed by <strong>Antoni Riera<\/strong> at IRB Barcelona, which synthesised the drug that inhibits TGF-beta activity, as well as <strong>Toni Berenguer<\/strong> <strong>Camille Stephan-Otto<\/strong> in the Biostatistics and Bioinformatics Facility at the same institute, who validated the similarity of human and mouse tumours. The study also involved the Department of Oncology and Pathology at the Hospital del Mar de Barcelona.<br><br>The study received funding from the BBVA Foundation, the Olga Torres Foundation, the Josef Steiner Foundation, the European Research Council, the Ministry of Economy and Competitiveness through ERDFs, the Bot\u00edn Foundation, and Santander Bank through its Global Santander Universities Division <strong>Eduard Batlle<\/strong> and <strong>Daniele Tauriello<\/strong> are also members of the CIBERONC network (Biomedical Research Networking Centre in Oncology), from which the lab receives funds for developing the studies.<br><br><strong>Reference article:<\/strong><br><br>Daniele VF Tauriello, Sergio Palomo-Ponce, Diana Stork, Antonio Berenguer-Llergo, Jordi Badia-Ramentol, Mar Iglesias, Marta Sevillano, Sales Ibiza, Adria Ca\u00f1ellas, Xavier Hernando-Momblona, Daniel Byrom, Joan A Matarin, Alexandre Calon, Elisa I Rivas, Angel R Nebreda, Antoni Riera, Camille Stephan-Otto Attolini and Eduard Batlle<br><br>TGF-beta drives immune evasion in genetically reconstituted colon cancer metastasis<br><i>Nature<\/i> (2018). doi: <a href=\"https:\/\/www.nature.com\/articles\/nature25492?error=cookies_not_supported&#038;code=c6d8e5a9-4924-4944-bd3d-4955ed910ec6\" target=\"_BLANK\">https:\/\/www.nature.com\/articles\/nature25492?error=cookies_not_supported&#038;code=c6d8e5a9-4924-4944-bd3d-4955ed910ec6<\/a><br><br>LINK TO THE VIDEO ANIMATION <a href=\"https:\/\/www.youtube.com\/watch?v=FdSvydBWVk0\" target=\"_BLANK\">LINK<\/a> (Google Drive) to scientific <a href=\"https:\/\/www.youtube.com\/watch?v=Yg1NTdoC8JU\" target=\"_BLANK\">images<\/a>, .<br><a href=\"https:\/\/drive.google.com\/drive\/folders\/1NYqeQKLcdXs7MYedTJsVx8ojWp3Ho_eJ?usp=sharing\" target=\"_BLANK\">LINK<\/a> (Google Drive) to scientific images, photos in the lab with the authors, press release and the summary of the article<br><br><strong>More information<\/strong> S\u00f2nia Armengou. Press Office. IRB Barcelona. 93 403 72 55\/618 294 070<br><br><br><\/div><div><strong>About IRB Barcelona<\/strong><br><br>Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence, a seal that was awarded in 2011. <strong>The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people\u2019s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science.<\/strong> Its 25 laboratories and seven core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer\u2019s, diabetes, and rare conditions. IRB Barcelona is an international centre that hosts 400 employees and 32 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the \u201cXarxa de Centres de Recerca de Catalunya\u201d (CERCA).<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0293b8 elementor-widget elementor-widget-text-editor\" data-id=\"e0293b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>20 October 2017<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Important scientific discovery with funding from the FOT A team headed by ICREA researcher Eduard Batlle discovers that immune system-stimulating treatments combined with a TGF-beta inhibitor are effective against colon cancer. The researchers developed a mouse model that mimics advanced human colon cancer. This model has allowed them to study the immune system response for [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4152,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[25],"tags":[],"class_list":["post-5961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-featured-news"],"_links":{"self":[{"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/posts\/5961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/comments?post=5961"}],"version-history":[{"count":0,"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/posts\/5961\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/media\/4152"}],"wp:attachment":[{"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/media?parent=5961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/categories?post=5961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.fundacioolgatorres.org\/en\/wp-json\/wp\/v2\/tags?post=5961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}